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目的观察57例肺癌患者围术期细胞免疫功能指标变化。方法连续选择近期接受手术治疗的肺癌患者57例,入选患者在手术前和术后2周时外周血T淋巴细胞亚群和NK细胞测定,并与同期健康体检者(对照组,31例)比较。结果57例肺癌患者围术期CD+3、CD+4、CD+4/CD+8明显低于对照组,而CD+8明显高于对照组(P<0.05～0.01);而肺癌患者术后2周时CD+3、CD+4、CD+4/CD+8明显高于手术前检测值,而CD+8明显低于后者(P<0.05～0.01)。结论肺癌患者存在明显的细胞免疫功能障碍,手术切除病灶可显著改善肺癌患者细胞免疫功能指标。
Objective To observe the changes of cellular immune function in 57 cases of lung cancer patients during perioperative period. Methods Fifty-seven consecutive lung cancer patients undergoing surgical treatment were enrolled in this study. Peripheral blood T lymphocyte subsets and NK cells were measured before and 2 weeks after operation. The results were compared with those of healthy controls (n = 31) . Results 57 patients with lung cancer had significantly lower CD + 3, CD 4, CD 4 + CD 8 during the perioperative period than those in the control group, while CD + 8 was significantly higher than those in the control group (P 0.05-0.01) CD + 3, CD + 4 and CD + 4 / CD + 8 at 2 weeks after operation were significantly higher than those before operation, while CD + 8 was significantly lower than the latter (P <0.05-0.01). Conclusion There are obvious cellular immune dysfunction in patients with lung cancer. Surgical resection lesions can significantly improve cellular immune function in patients with lung cancer.