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研究发现对肾综合征出血热（ＨＦＲＳ）病毒Ａ１６株（Ｈａｎｔａａｎ型）感染小鼠母鼠的保护作用与免疫母鼠所用病毒株的血清型和乳鼠的感染途径有关．病毒Ａ＿１６株免疫的小鼠母鼠对腹腔和脑内感染的其所生乳鼠的保护率均为１００％。病毒７６－１１８株（Ｈａｎｔａａｎ型）免疫的小鼠母鼠对腹腔感染的其所生乳鼠的保护率为１００％（感染剂量为１０￣（５．２）和１０￣（６．２）ＬＤ＿５０）至９１％（感染剂量为１０￣（７．２）ＬＤ＿５０），而对脑内感染的。乳鼠依感染剂量（１０￣（５．２）１０￣（６．２）和１０￣（７．２）ＬＤ５０）不同保护率分别为６０％、５０％和２０％。用病毒Ｒ２２株（Ｓｅｏｕｌ型）免疫的小鼠母鼠对腹腔感染的其所生乳鼠保护率均为１００％。而对脑内感染的乳鼠依感染剂量（１０（３．２）或１０￣（４．２）～１０￣（７．２）ＬＤ＿５０）不同保护率为４０％或０．
The study found that protective effect of the Hantaan-type mice infected by HFRS virus was related to the serotypes of the virus strains used in the immunized mice and the infection route of the suckling mice. The protective rate of mice born in mice immunized with virus A_16 strain to their born sufferers infected intraperitoneally and intracerebrally was 100%. The protective rate of 100% (the dose of 10 ~ (5.2) and 10 ~ (6.2) LD_50) to the mice born from mice infected with virus type 76-118 (Hantaan type) To 91% (infection dose of 10 ~ (7.2) LD_50), while the brain infection. The protection rates for sucking mice were 60%, 50% and 20%, respectively, at the doses of 10 to 5.2 (10 to 6.2) and 10 to (7.2) LD50. Mice immunized with the virus R22 strain (Seoul type) had 100% protection of their born neonates with intraperitoneal infection. However, the rate of protection was 40% or 0 in different doses (10 (3.2) or 10 ~ (4.2) ~10 ~ (7.2) LD_50).