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目的:总结近年来关于胸苷磷酸化酶(TP)在结直肠癌组织中表达临床意义的研究现状。方法:应用PubMed、Elsevier Sciencedirect、CNKI及万方全文数据库检索系统,以胸苷磷酸化酶和结直肠癌为关键词,检索2005-01-2011-06发表的相关文献。纳入标准:1)TP在结直肠癌及转移组织中的表达及其促血管新生、抗细胞凋亡等生物学作用。2)TP与5-氟尿嘧啶(5-FU)前体类药物靶向治疗的关系。根据纳入标准分析文献29篇。结果:TP对于结直肠癌的影响是双重性的,其在肿瘤血管新生、转移、复发以及抗细胞凋亡等过程中均发挥重要作用,高表达TP的患者往往预后不良。另外,TP又在5-FU前体药物的化疗过程中起着关键作用,增加TP的表达很可能可以增强5-FU前体药物的化疗效果。结论:TP在结直肠癌组织中的表达对结直肠癌靶向治疗和预后有着非常重要的临床意义。
OBJECTIVE: To summarize the research status of the clinical significance of thymidine phosphorylase (TP) expression in colorectal cancer tissues in recent years. METHODS: PubMed, Elsevier Sciencedirect, CNKI and Wanfang full-text database retrieval system were used to search for relevant articles published from January 2005 to November 2011 with thymidine phosphorylase and colorectal cancer as the key words. Inclusion criteria: 1) TP expression in colorectal cancer and metastasis and its angiogenesis, anti-apoptosis and other biological effects. 2) TP and 5-fluorouracil (5-FU) precursor drug-targeted therapy. According to the inclusion criteria, 29 articles were analyzed. Results: TP had a dual effect on colorectal cancer, which played an important role in tumor angiogenesis, metastasis, recurrence and anti-apoptosis. Patients with high expression of TP often had poor prognosis. In addition, TP plays a pivotal role in the chemotherapy of 5-FU prodrugs. Increasing the expression of TP is likely to enhance the chemotherapeutic effect of 5-FU prodrugs. Conclusion: The expression of TP in colorectal cancer has a very important clinical significance for the targeted therapy and prognosis of colorectal cancer.