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目的观察幽门螺杆菌(Helicobacter pylori,H.pylori)相关性胃癌患者血清白介素-4(IL-4)和干扰素-γ(IFN-γ)含量的变化,以探讨H.pylori感染时宿主TH1/TH2细胞的免疫应答变化。方法采用酶联免疫吸附测定法测定7例H.pylori阴性胃癌患者和13例H.pylori阳性胃癌患者血清IL-4及IFN-γ的含量。结果 2组患者血清IL-4及IFN-γ含量差异均无统计学意义(P=0.897)。结论 H.pylori感染对胃癌患者TH1/TH2细胞的免疫应答无明显影响。
Objective To investigate the changes of serum interleukin-4 (IL-4) and interferon-γ (IFN-γ) in Helicobacter pylori (Hp) TH2 cells immune response changes. Methods Serum levels of IL-4 and IFN-γ in 7 patients with H.pylori-negative gastric cancer and 13 patients with H.pylori-positive gastric cancer were determined by enzyme-linked immunosorbent assay (ELISA). Results There was no significant difference in serum IL-4 and IFN-γ between the two groups (P = 0.897). Conclusion H.pylori infection has no significant effect on the immune response of TH1 / TH2 cells in gastric cancer patients.