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目的探讨慢性HBV感染者对干扰素抗病毒疗效反应性差异与KIR基因型的相关性。方法对56名慢性HBV感染α-干扰素有效应答者(实验组)和57名慢性HBV感染干扰素无应答或部分应答者(对照组)分别进行KIR基因分型,比较2组间KIR基因型及单体型的差异。结果 AH基因型在实验组中的分布频率明显高于对照组(2χ=7.222 4,P<0.01),AF基因型及1型单体型在对照组中的分布频率明显高于实验组(2χ=10.057 5,P<0.01;2χ=16.328 3,P<0.01)。A组单体型在对照组中的分布高于实验组(2χ=5.982 8,P<0.05)。而B组则相反,在实验组中的分布高于对照组(2χ=5.983 0,P<0.05)。结论 AH基因型及B组单体型可能与α-干扰素抗病毒有效应答有关,AF基因型及1单体型和A组单体型可能与α-干扰素抗病毒疗效无应答或部分应答有关。
Objective To investigate the relationship between the response to interferon antiviral therapy and KIR genotype in patients with chronic HBV infection. Methods KIR genotyping was performed in 56 patients with effective response to interferon-alpha (experimental group) and 57 non-responders with chronic HBV infection or with partial response (control group) respectively. KIR genotypes were compared between two groups And haplotype differences. Results The distribution frequency of AH genotype in the experimental group was significantly higher than that in the control group (2χ = 7.222 4, P <0.01). The distribution frequency of AF genotype and type 1 haplotype in the control group was significantly higher than that in the experimental group = 10.057 5, P <0.01; 2χ = 16.328 3, P <0.01). The distribution of haplotypes in group A was higher in the control group than in the experimental group (2χ = 5.982 8, P <0.05). On the contrary, in group B, the distribution in experimental group was higher than that in control group (2χ = 5.983 0, P <0.05). Conclusions AH genotype and haplotype B may be related to the effective response to interferon-alpha antiviral therapy. The AF genotypes and haplotypes of haplotype 1 and haplotype A may be non-responsive or partially responsive related.