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前文曾报道电离辐射后动物肠道运动功能发生明显紊乱可能与ACh含量变化有关。我们同时观察到这种运动功能的紊乱与小肠组织中ACh含量的增高在程度上并不完全一致。这提示除了ACh含量增高外可能还存在其它影响肠道平滑肌运动的因素。Kagnoff在讨论照后动物小肠运动功能变化机理时曾提出:小肠平滑肌M受体可能发生某些变化的设想。但是,至今有关这方面的研究尚未见到报道。因此研究平滑肌M受体对探讨照射后小肠运动功能紊乱的产生机制及其防治具有一定的理论和实际意义。本文观察丙线照射后豚鼠离体回肠对ACh作用的收缩反应及其平滑肌M受体的变化情
It has been previously reported that significant disturbance of intestinal motility after exposure to ionizing radiation may be related to changes in ACh content. We also observed that the disturbance of motor function was not completely consistent with the increase of ACh in intestinal tissue. This suggests that in addition to increased ACh content there may be other factors that affect intestinal smooth muscle movement. Kagnoff, in discussing the mechanism of animal intestinal motility after irradiation, proposed the idea that some changes may occur in the M receptor of small intestinal smooth muscle. However, up to now, there is no report on this aspect. Therefore, the study of smooth muscle M receptor to explore the mechanism of small intestine dysfunction after irradiation and its prevention and treatment has a certain theoretical and practical significance. In this paper, we observed the contractile response of isolated guinea pig ileum to ACh and the changes of its M receptor