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目的:检测肾脏损伤因子-1(KIM-1)、胱抑素C(Cys C)及β2微球蛋白(β2-MG)在OSAHS患者中的表达水平,探索其对OSAHS患者早期肾功能损伤的评估及临床意义。方法:选取PSG监测OSAHS阳性的患者80例作为实验组,同时以OSAHS阴性者15例作为对照组,均在清晨抽取空腹静脉血检测Cys C的水平,留取中段晨尿离心后用双抗体夹心酶联免疫吸附法(ELISA)检测KIM-1的水平,所有实验数据均用SPSS13.0统计软件进行分析和比较。结果:1根据AHI变化分组检测结果:KIM-1在中度及重度患者尿中的水平高于正常人(P<0.01),Cys C、β2-MG在重度患者血中的水平均高于正常人(P<0.01),在轻度、中度、重度3组间的表达,组间两两比较,KIM-1在3组间差异均有统计学意义,Cys C、β2-MG均只在重度患者血中的水平高于轻度、中度患者(P<0.01)。2根据LSaO_2变化分组检测结果:KIM-1、Cys C、β2-MG在重度组中的水平均高于正常对照组(P<0.01),在轻、中、重度3组间的表达,组间两两比较,在重度组中的水平均高于轻、中度组中的水平(P<0.01)。3KIM-1、Cys C及β2-MG组间以及与AHI之间均呈正相关(P<0.01)。4在OSAHS患者中,KIM-1、Cys C及β2-MG均与LSaO_2呈负相关(P<0.01)。结论:KIM-1可以作为监测OSAHS患者早期肾功能损伤的灵敏指标,并且按照AHI分组时评价OSAHS患者早期肾功能损伤的价值优于按照LSaO_2分组。
OBJECTIVE: To detect the expression of KIM-1, Cys C and β2-MG in patients with OSAHS and to explore the effect of KIM-1 on the early renal dysfunction in patients with OSAHS Evaluation and clinical significance. Methods: 80 patients with OSAHS positive PSG were selected as the experimental group and 15 patients with OSAHS negative as the control group. Fasting venous blood was collected to detect the level of Cys C in the early morning. After taking the middle morning urine, The level of KIM-1 was detected by enzyme-linked immunosorbent assay (ELISA). All the experimental data were analyzed by SPSS 13.0 statistical software. Results: 1 According to the change of AHI, the level of KIM-1 in moderate and severe patients was higher than that in normal people (P <0.01). The levels of Cys C and β2-MG in severe patients were higher than normal (P <0.01). The expression of KIM-1 was significantly different between the three groups in the mild, moderate and severe groups. The Cys C and β2-MG were only in Severe patient blood levels were higher than in mild to moderate patients (P <0.01). 2 According to LSaO_2, the levels of KIM-1, Cys C, β2-MG in severe group were higher than those in normal control group (P <0.01) In any pairwise comparison, the levels in the severe group were higher than those in the mild and moderate groups (P <0.01). There was a positive correlation between 3KIM-1, Cys C, β2-MG and AHI (P <0.01). 4 In OSAHS patients, KIM-1, Cys C and β2-MG were negatively correlated with LSaO_2 (P <0.01). Conclusion: KIM-1 can be used as a sensitive indicator to monitor early renal injury in patients with OSAHS. The value of KIM-1 in early diagnosis of OSAHS in patients with OSAHS is better than that in LSaO_2.