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目的探讨部分HLA-Ⅱ类等位基因与妊娠期糖尿病(GDM)的相关性,从免疫遗传学角度比较GDM和(T2DM)遗传基础的异同.观测GDM、T2DM患者血浆脂联素水平的变化,分析血浆脂联素与胰岛素抵抗的关系,探讨脂联素在GDM发病中的作用,寻找预测GDM远期可能发生糖尿病的临床指标.方法采用PCR-SSP检测48例GDM和48例T2DM的部分HLA-Ⅱ等位基因频率,并与48名正常孕妇比较;选取GDM、T2DM患者、正常孕妇组各40例作为研究对象,应用放免法测定受试者血浆脂联素水
To investigate the relationship between some HLA-Ⅱ alleles and gestational diabetes mellitus (GDM) and to compare the genetic basis of GDM and (T2DM) from the perspective of immune genetics.Observation of plasma adiponectin levels in GDM and T2DM patients, To analyze the relationship between plasma adiponectin and insulin resistance and to explore the role of adiponectin in the pathogenesis of GDM and to find out the clinical indicators of possible diabetes in GDM.Methods 48 cases of GDM and 48 cases of T2DM were detected by PCR- -Ⅱ allele frequency and compared with 48 normal pregnant women; 40 cases of GDM, T2DM patients and normal pregnant women group were selected as the research object, the content of plasma adiponectin