Rhodium-catalyzed selective[2+2+2]cyclizations of 1,6-diynes with monoynes leading to isoindolines a

• 出 处: Chinese Chemical Letters
• 发表日期: 2010年01期
• 关键词: catalyzed cyclization intramolecular benzene aromatic dilution rings readily con

A highly efficient and selective[2+2+2]cyclization of diynes and monoalkynes was catalyzed by rhodium under room temperature in water/THF mixed solvent,affording isoindolines and isobenzofurans in good to excellent yields.The center atoms (N,O) in the diynes showed a significant effect for the cyclization.

A highly efficient and selective [2 + 2 + 2] cyclization of diynes and monoalkynes was catalyzed by rhodium under room temperature in water / THF mixed solvent, affording isoindolines and isobenzofurans in good to excellent yields.The center atoms (N, O) in the diynes showed a significant effect for the cyclization.