论文部分内容阅读
用放射配基结合分析法测定了外源性及内源性哮喘患者外周白细胞糖皮质激素受体（ＧＣＲ）水平，同时测定其血浆皮质醇水平。结果发现哮喘患者ＧＣＲ水平较正常对照组明显降低（Ｐ＜０．０１），其降低程度与疾病初发年龄、病程密切相关，而哮喘患者血浆皮质醇水平与正常对照组无显著差异性。提示哮喘患者肾上腺皮质功能尚未受到明显损害，但其ＧＣＲ功能存在异常。关于哮喘患者ＧＣＲ功能异常原因，我们推测与哮喘患者遗传倾向有关，同时与环境因素反复刺激、疾病反复发作有关。
Peripheral leukocyte glucocorticoid receptor (GCR) levels in extrinsic and endogenous asthmatic patients were measured by radioligand binding assay and plasma cortisol levels were also determined. The results showed that the level of GCR in asthmatic patients was significantly lower than that in the normal controls (P <0.01). The degree of reduction was closely related to the age and course of the disease. However, the plasma cortisol level in asthmatic patients was not significantly different from that in the normal controls. Tip asthma patients adrenal function has not been significantly damaged, but its abnormal GCR function. About asthma patients with abnormal GCR function, we speculate that the genetic predisposition of patients with asthma, and repeated stimulation of environmental factors, recurrent disease.