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研究了鼠疫菌ＶｗＰｇｍ突变与毒力的关系。青海疫源地内青藏高原型和祁连山型鼠疫菌ＶｗＰｇｍ的突变率无明显差异。经人工培养２０～２４代后，Ｖｗ＋菌株可能为Ｖｗ－，毒力明显降低，Ｐｇｍ＋菌株除１株转为Ｐｇｍ－，１株为Ｐｇ±，其余３株仍为Ｐｇｍ＋，Ｖｗ毒力因子具有更不稳定特点。测定了同一菌株中不同Ｐｇｍ特征的毒力，Ｐｇｍ＋细胞里强毒，Ｐｇｍ－鼠疫菌经１０代小白鼠传代，均无Ｐｇｍ＋细胞回复。
The relationship between VwPgm mutation and virulence of Y. pestis was studied. There was no significant difference in the mutation rate of VwPgm between Qinghai-Tibet Plateau and Qilian Mountain Y. pestis in Qinghai epidemic area. After cultured for 20-24 generations, the virulence of Vw + strain was significantly lower than that of Vw-, Pgm + strain was Pgm-, one was Pg ± and the other three strains were still Pgm + Unstable characteristics. The virulence of different Pgm characteristics in the same strain was determined. The virulent Pgm + cells in Pgm + cells were passaged.