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目的：比较观察内毒素及肿瘤坏死因子在胰源性肺损伤动物实验中不同时间的变化及致损作用。方法：在制备胰源性肺损伤大鼠模型基础上，给予通里攻下中药治疗，分设治疗组、造模组、正常对照组，并在三组不同时间检测内毒素及肿瘤坏死因子的含量。结果：治疗组与造模组之间差别显著（Ｐ＜００１），造模组与正常对照组之间差别亦显著（Ｐ＜００１）。结论：内毒素及肿瘤坏死因子参与了胰源性肺损伤的全过程，且通里攻下治疗起到了清除内毒素及肿瘤坏死因子的作用
OBJECTIVE: To compare the effects of endotoxin and tumor necrosis factor (TNF) on pancreatic-derived lung injury in animal experiments at different time and lesion. Methods: On the basis of the preparation of rat model of pancreatic lung injury, Tongli was given traditional Chinese medicine treatment and divided into treatment group, model group and normal control group. The levels of endotoxin and tumor necrosis factor . Results: The difference between the treatment group and the model group was significant (P <001), and the difference between the model group and the normal control group was also significant (P <001). Conclusion: Endotoxin and tumor necrosis factor are involved in the whole process of pancreatic-derived lung injury. Tongling treatment has played a role in clearance of endotoxin and tumor necrosis factor