论文部分内容阅读
目的了解宝安区O型孕妇血清Ig G抗A(B)效价与新生儿ABO溶血之间的关系,为临床诊断及预防提供参考依据。方法采用国产微柱凝胶法对3038例孕16~40w的O型孕妇(其丈夫为A型、B型、AB型)作不规则抗体筛查和Ig G抗A(B)效价的测定,以1+凝集强度为阳性判断标准,并以此血清稀释倍数的倒数为效价,并与临床确诊为ABO血型不合新生儿溶血病(ABO-HDN)209例产妇作相关性分析。结果 3038例O型孕妇Ig G抗A(B)的效价≥256为45.69%(1388/3038),其中,夫妇A-O血型不合的O型孕妇为50.26%(681/1355),B-O血型不合为41.94%(507/1209),AB-O型不合的为42.19%(200/474);209例临床确诊为新生儿ABO-HDN的O型产妇Ig G抗体效价≥256为98.56%(206/209)。结论国产微柱凝胶法检测夫妇血型不合的O孕妇血清Ig G抗体效价应设为<256较为合理,对临床ABO-HDN的预测、诊断及防治有重要意义。
Objective To understand the relationship between IgG anti-A (B) titer and neonatal ABO hemolysis in O-type pregnant women in Bao’an District, and provide reference for clinical diagnosis and prevention. Methods A total of 3038 O-pregnant women (whose husbands were Type A, Type B and Type AB) of pregnancy were screened for irregular antibodies and IgA anti-A (B) titer , And 1+ agglutination intensity was taken as the positive criterion. The reciprocal of the serum dilution was used as the titer, and the correlation was analyzed with 209 cases of ABO-HDN clinically diagnosed as ABO-type non-hemolytic disease. Results The titer ≥256 of IgG anti-A (B) in 3038 O-pregnant women was 45.69% (1388/3038). Among them, 50.26% (681/1355) 41.94% (507/1209), and 42.19% (200/474) in AB-O type. The IgG antibody titer of O-type maternal IgG in 209 cases diagnosed as neonatal ABO-HDN≥256 was 98.56% (206 / 209). Conclusion The domestic microcolumn gel method for the detection of serum IgG antibody titer of O blood in pregnant women with different blood type should be set as <256, which is of great significance for the prediction, diagnosis and prevention of clinical ABO-HDN.