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一、病例报告混合性结缔组织病(MCTD)患者10例,其中女性9例;平均年龄38岁。主诉以雷诺氏现象最多,共6例。抗核抗体双重免疫扩散法均阳性,被动红细胞凝集法的核糖核酸酶(RNA)过敏性抗体价均高达5120倍以上,而抵抗性抗体价即抗平滑肌(sm)抗体均在40倍以下。肾活检8例,其中尿检阳性的6例中有3例为膜性肾病,2例为肾小球间质增殖性肾炎(IgA 沉着阳性)、1例呈微小变化型,为尿检正常的2例只是微小变化型。除1例以后未来院的患者外,从发病至现今已4～6年,此间的治疗,7例采用激素,1例表现为肾病综合征的膜性肾病完全缓解,其他病例除1
First, the case report mixed connective tissue disease (MCTD) in 10 patients, including 9 females; the average age of 38 years. The main complaint to Raynaud’s phenomenon, a total of 6 cases. Anti-nuclear antibody double immunodiffusion method were positive, passive red blood cell agglutination of the ribonuclease (RNA) allergic antibody prices were as high as 5120 times, and the resistance of anti-smooth muscle antibody (sm) are 40 times less. 8 cases of renal biopsy, of which 6 cases of urinalysis positive in 3 cases of membranous nephropathy, 2 cases of glomerular mesangial proliferative glomerulonephritis (IgA-positive), 1 cases showed a small change in urine for the normal 2 cases Just a small change. In addition to a future hospital future patients, from the onset to the present 4 to 6 years, the treatment here, 7 cases with hormones, 1 case showed nephrotic syndrome membranous nephropathy complete remission, other cases except 1