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目的了解新兴县育龄期妇女中地海贫血的发生情况,充分认识地中海贫血筛查在婚检、孕检、产检的重要意义。方法对1826例育龄期妇女进行地中海贫血初筛,并应用法国Sebia全自动电泳分析系统进行血红蛋白电泳,通过检测Hb各组分的含量,初步分为属于α地贫或β地贫,再通过基因诊断确诊。结果 1826例血标本中,检出地中海贫血及地中海贫血基因携带者203例,占11.12%。结论广东省云浮市新兴县属地中海贫血高发区,因此开展婚前、产前检查十分重要,对降低出生缺陷,提高出生人口素质,具有十分重要而积极的社会意义。
Objective To understand the incidence of thalassemia and anemia among women of childbearing age in Xinxing County and to fully understand the significance of thalassemia screening in premarital examination, pregnancy test and birth control. Methods A total of 1826 women of childbearing age were enrolled in this study. Hemaggluin electrophoresis was performed using the French Sebia automated electrophoresis system. The levels of Hb in each group were initially divided into α thalassemia or β thalassemia, Diagnosis confirmed. Results Among 1826 blood samples, 203 cases of thalassemia and thalassemia gene carriers were detected, accounting for 11.12%. Conclusions Xinxing County, Yunfu City, Guangdong Province, is endemic to the area of thalassemia. Therefore, it is very important to carry out premarital and prenatal examinations. It is of great social significance to reduce birth defects and improve the quality of birth population.