论文部分内容阅读
目的:观察异长春花硷（NVB）联合顺铂（PDD）组成NP方案治疗非小细胞肺癌的疗效。方法:NP方案联合治疗32例晚期非小细胞肺癌（NSCLC）,其中男25例,女7例;Ⅲ期23例,Ⅳ期9例。用药方法为,NVB25mg/m2,iv,d1,d8;PDD80mg/m2,iv,d1每21天重复。结果:全组32例中CR1例,PR16例,SD12例,PD3例,总有效率为53、1％。NVB限制性毒性为白细胞下降（96.8％）,其中Ⅲ、Ⅳ度为56.0％;静脉炎发生率为40.6％。结论:以NVB和PDD联合治疗NSCLC有效率较高,是一个较好的抗肺癌化疗方案。
OBJECTIVE: To observe the efficacy of NP regimen in the treatment of non-small cell lung cancer with vinorelbine (NVB) combined with cisplatin (PDD). Methods: Thirty-two patients with advanced non-small-cell lung cancer (NSCLC) were treated with NP regimen, including 25 males and 7 females; 23 patients with stage III and 9 patients with stage IV. Medication methods were: NVB 25 mg/m2, iv, d1, d8; PDD 80 mg/m2, iv, d1 repeated every 21 days. Results: In the whole group of 32 cases, there were 1 CR, 16 PR, 12 SD, and 3 PD. The total effective rate was 53,1%. The NVB-restricted toxicity was a decrease in white blood cells (96.8%), of which III and IV were 56.0%; the incidence of phlebitis was 40.6%. Conclusion: The combination of NVB and PDD in the treatment of NSCLC is highly effective and is a good anti-lung cancer chemotherapy.