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目的:研究B7-H3在胃癌组织中的表达及其与各临床病理变量之间的相关性。方法:采用免疫组织化学法检测113例胃癌手术标本中B7-H3蛋白的表达,分析其与肿瘤浸润性T淋巴细胞及各临床病理参数间的相关性。结果:B7-H3在胃癌组织中高表达(46.9%,53/113);B7-H3的表达与肿瘤浸润性T淋巴细胞呈负相关,P<0.05。淋巴结阳性组中B7-H3+群的百分比(54.8%,40/73)高于无淋巴结转移组(32.5%,13/40),P<0.05。Ⅰ、Ⅱ期患者标本中B7-H3的阳性表达率要明显低于Ⅲ+Ⅳ期组,P<0.05。结论:B7-H3在胃癌组织中高表达,与肿瘤分期、淋巴结转移正相关,与肿瘤浸润T淋巴细胞呈负相关。B7-H3可能通过抑制间质中T细胞的浸润介导胃癌肿瘤免疫逃逸。
Objective: To study the expression of B7-H3 in gastric carcinoma and its correlation with clinicopathological variables. Methods: The expression of B7-H3 protein in 113 specimens of gastric cancer was detected by immunohistochemistry. The correlation between the expression of B7-H3 protein and tumor infiltrating T lymphocytes and clinicopathological parameters was analyzed. Results: B7-H3 was highly expressed in gastric carcinoma (46.9%, 53/113). The expression of B7-H3 was negatively correlated with tumor infiltrating T lymphocytes (P <0.05). The percentage of B7-H3 + population (54.8%, 40/73) in lymph node positive group was higher than that in non-lymph node metastasis group (32.5%, 13/40), P <0.05. The positive expression rate of B7-H3 in stage Ⅰ and Ⅱ patients was significantly lower than that in stage Ⅲ + Ⅳ, P <0.05. CONCLUSION: B7-H3 is overexpressed in gastric cancer tissues and positively correlated with tumor stage and lymph node metastasis, but negatively correlated with tumor infiltrating T lymphocytes. B7-H3 may mediate gastric cancer immune escape by inhibiting the infiltration of T cells in stroma.