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实验观察了柴胡鳖甲汤对猪血清诱导大鼠免疫损伤性肝纤维化的治疗作用。结果发现,经柴胡鳖甲汤治疗后,使肝纤维增生减少68.6％;大鼠腹腔巨噬细胞吞噬功能和产生IL-2,以及脾T淋巴细胞对Con A的增殖反应和产生IL-2的能力,接近正常水平;与大鼠免疫损伤性肝纤维化模型比较,具有下调免疫功能的作用,P值<0.01。提示柴胡鳖甲汤对减轻猪血清诱导大鼠免疫损伤性肝纤维化的免疫损伤程度,有一定的治疗作用。
The effect of Chaihu Biejia Decoction on immune serum-induced liver fibrosis in rats was observed experimentally. The results showed that after treatment with Chaihu Fujia Decoction, liver fibrosis was reduced by 68.6%; rat peritoneal macrophage phagocytosis and production of IL-2, and splenic T lymphocyte proliferative response to Con A and IL-2 production The ability to approach normal levels; compared with the immune-impaired liver fibrosis model in rats, has the effect of down-regulating immune function, P value < 0.01. It is suggested that the decoction of Chaihu Biejia Decoction has a certain therapeutic effect on reducing the degree of immune damage induced by swine serum induced immune-induced liver fibrosis in rats.