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强直性脊柱炎(ankylosing spondylitis,AS),属于血清阴性脊柱关节病,病变部位为骶髂关节和脊柱,累及肌腱、韧带附着点以及滑膜软骨,引起纤维性和骨性强直。该病以男性多发,男女比例约为2:1。初始发病年龄约为18～22岁。据报道AS与HLA-B27相关,有家族聚集性。我国AS患者的HLA-B27阳性率达90%,HLA-B27阳性者发病的相对危险度为36。强直性脊柱炎的危害较
Ankylosing spondylitis (AS) belongs to the seronegative spondyloarthropathies. The lesions are sacroiliac joints and spine, involving tendons, ligament attachment points and synovial cartilage, resulting in fibrous and bony ankylosis. The disease is predominantly male, with a ratio of men to women of about 2: 1. The initial age of onset is about 18 to 22 years old. AS is reported to be associated with HLA-B27 and has familial aggregation. The prevalence of HLA-B27 was 90% in Chinese AS patients, and the relative risk of HLA-B27-positive patients was 36. Ankylosing spondylitis hazards