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采用高效液相色谱法测定单剂量口服呋喃妥因缓释微丸 (NF PE)和市售肠溶包衣片(NF TA)后的尿药浓度 ,研究该药缓释微丸的药动学参数和生物利用度 ,并考察其体内外相关性 .结果表明 :呋喃妥因缓释微丸相对于肠溶包衣片的生物利度为 130 2 5 % ;供试品呋喃妥因缓释微丸和对照品肠溶包衣片的消除速率常数分别为 0 44 98h-1、0 82 0 2h-1,前者的消除半衰期(t1/ 2 )及平均滞留时间 (MRT)均较后者有所延长 ;该药体内吸收率与体外溶出度相关性显著 (r =0 972 4) .
The urinary drug concentrations of single-dose oral administration of nitrofurantoin (NF PE) and enteric-coated (NFTA) tablets were determined by high performance liquid chromatography (HPLC) Bioavailability and their in vitro and in vivo correlation.The results showed that the bioavailability of nitrofurantoin sustained-release pellets relative to enteric-coated tablets was 130 2 5%; test sample nitrofurantoin sustained-release pellets and control enteric-coated The elimination rate constants of the tablets were 0 44 98 h-1 and 0 82 0 2 h-1, respectively. The elimination half-life (t1 / 2) and mean retention time (MRT) of the former were longer than the latter. Correlation with in vitro dissolution was significant (r = 0 972 4).