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目的探讨免疫组化标记物波形蛋白(Vimentin)、癌胚抗原(CEA)、雌激素受体(ER)、孕激素受体(PR)和p16蛋白在子宫内膜样腺癌与宫颈腺癌鉴别诊断中的表达和意义。方法采用免疫组织化学染色法检测48例子宫内膜样腺癌和21例宫颈腺癌患者肿瘤组织中Vimentin、CEA、ER、PR和p16的表达,并分析其临床意义。结果子宫内膜样腺癌患者肿瘤组织中Vimentin、CEA、ER、PR和p16阳性表达率分别为79.2%、31.3%、87.5%、81.3%和20.8%。宫颈腺癌患者肿瘤组织中Vimentin、CEA、ER、PR和p16阳性表达率分别为14.3%、90.5%、23.8%、42.9%和81.0%。经2检验,Vimentin(2=25.50)、CEA(2=20.50)、ER(2=27.29)、PR(2=10.17)和p16(2=22.17)在子宫内膜样腺癌和宫颈腺癌患者肿瘤组织中阳性表达率的差异均有统计学意义(P<0.05)。结论免疫组化法检测Vimentin、CEA、ER、PR和p16的表达有助于临床鉴别诊断宫颈腺癌和子宫内膜样腺癌。
Objective To investigate the expression of vimentin, carcinoembryonic antigen (CEA), estrogen receptor (ER), progesterone receptor (PR) and p16 protein in endometrioid adenocarcinoma and cervical adenocarcinoma Diagnosis in the expression and significance. Methods Immunohistochemical staining was used to detect the expression of Vimentin, CEA, ER, PR and p16 in 48 cases of endometrioid adenocarcinoma and 21 cases of cervical adenocarcinoma and their clinical significance was analyzed. Results The positive rates of Vimentin, CEA, ER, PR and p16 in endometrioid adenocarcinoma were 79.2%, 31.3%, 87.5%, 81.3% and 20.8% respectively. The positive rates of Vimentin, CEA, ER, PR and p16 in cervical adenocarcinoma were 14.3%, 90.5%, 23.8%, 42.9% and 81.0% respectively. The levels of Vimentin (2 = 25.50), CEA (2 = 20.50), ER (2 = 27.29), PR (2 = 10.17) and p16 (2 = 22.17) There was significant difference in the positive expression rate between tumor and cervical adenocarcinoma (P <0.05). Conclusion Immunohistochemical detection of Vimentin, CEA, ER, PR and p16 expression is helpful in the differential diagnosis of cervical adenocarcinoma and endometrioid adenocarcinoma.