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Moynahan等报告肠病性肢端皮炎患者的低水平血浆锌,经用锌补充治疗后获得了临床痊愈。这些发现已被证实,但对于锌治疗本病的机理尚不完全了解。Loembeck等证实肠病性肢端皮炎病人的肠对锌吸收不良,可能是由于肠道嗜酸颗粒性细胞的超微结构损害所致。有人在缺乏锌的鼠肠中也发现有类似的损害。Elmes认为吸收不良不是由于嗜酸颗粒性细胞的形态学损害所致,这些损害是缺乏
Moynahan et al reported low levels of plasma zinc in patients with enterocolitis acral dermatitis and achieved clinical recovery after zinc supplementation. These findings have been confirmed, but the mechanism of zinc for the treatment of this disease is not fully understood. Loembeck et al confirmed poor intestinal malabsorption of zinc in patients with enteric acutritis, possibly due to ultrastructural damage of intestinal eosinophilic granulosa cells. Some people also found similar damage in zinc-deficient rat intestines. Elmes believes that malabsorption is not due to morphological damage of eosinophilic granulosa cells, which are devoid of damage