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为研究川楝子的化学成分,利用硅胶柱色谱及制备型高效液相色谱等方法对川楝子的乙酸乙酯提取物进行分离纯化,得到3个柠檬苦素类化合物,根据理化性质及一维和二维核磁共振谱鉴定其结构分别为:24,25,26,27-tetranorapotirucalla-(apoeupha)-1α-tigloyloxy-3α,7α-dihydroxyl-12α-acetoxyl-14,20,22-trien-21,23-epoxy-6,28-epoxy(1)、nimbolinin B(2)和trichilinin D(3)。其中化合物1为新化合物,化合物2为首次从川楝子中分离得到。
In order to study the chemical constituents of Rhizoma Dioscoreae, the ethyl acetate extracts of Ligusticum chuanxiong were separated and purified by silica gel column chromatography and preparative high performance liquid chromatography. Three limonoid compounds were obtained according to their physicochemical properties. The two-dimensional NMR spectra identified their structures as: 24,25,26,27-tetranorapotirucalla-(apoeupha)-1α-tigloyloxy-3α,7α-dihydroxyl-12α-acetoxyl-14,20,22-trien-21, 23-epoxy-6, 28-epoxy (1), nimbolinin B (2) and trichilinin D (3). Among them, compound 1 is a new compound, and compound 2 is first isolated from Fructus Gardeniae.