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Girdin蛋白是一种新的肌动蛋白结合蛋白,在多种肿瘤细胞和不成熟的内皮细胞中处于中、高表达水平。Girdin蛋白参与多种细胞内活动,包括肌动蛋白骨架的稳定和重构、磷脂酰肌醇3-激酶/蛋白激酶B信号转导通路以及与Gα的相互作用,并且能促进肿瘤细胞的增殖、迁移、血管新生和自我吞噬等的调节,最终导致肿瘤细胞的转移浸润。Girdin蛋白在恶性肿瘤的发生、发展中起着重要的作用。
Girdin is a novel actin-binding protein that is at moderate and high levels in a variety of tumor cells and immature endothelial cells. Girdin proteins are involved in a variety of intracellular activities including the stabilization and remodeling of the actin cytoskeleton, the phosphatidylinositol 3-kinase / protein kinase B signaling pathway, and Gα interactions and promote tumor cell proliferation, Migration, angiogenesis and self-phagocytosis, eventually leading to metastasis of tumor cells. Girdin protein plays an important role in the occurrence and development of malignant tumors.