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目的:研究小檗碱甘草酸络盐(BGC)的抗糖尿病作用。方法:4月龄GK大鼠随机分为5组,模型对照组、阳性对照组、低剂量给药组、中剂量给药组和高剂量给药组,另取Wisar大鼠10只作为正常对照组;各组大鼠分别每日ig BGC、小檗碱或生理盐水共6周,给药4周后测空腹血糖和餐后血糖。6周后取血测血脂(TG、TC、HDL-c、LDL-c)、MDA、FFA、糖化血清蛋白、胰岛素水平;取肾、胰组织作病理切片。结果:与模型组相比,GK大鼠给药组餐后血糖下降,糖化血清蛋白和胰岛素水平降低,血清LDL和MDA降低;GK大鼠肾脏、胰腺的组织形态学病变改善。结论:BGC具有抗糖尿病作用。
Objective: To study the anti-diabetic effect of berberine glycyrrhizin complex salt (BGC). METHODS: Four-month-old GK rats were randomly divided into five groups: model control group, positive control group, low-dose administration group, middle-dose administration group and high-dose administration group, and another 10 Wisar rats were used as normal controls. Each group of rats was treated with ig BGC, berberine or saline for 6 weeks, and fasting blood glucose and postprandial blood glucose were measured 4 weeks after administration. Six weeks later, blood was taken to measure blood lipids (TG, TC, HDL-c, LDL-c), MDA, FFA, glycosylated serum protein, and insulin levels. Renal and pancreatic tissues were taken for pathological examination. RESULTS: Compared with the model group, postprandial blood glucose decreased, serum glycosylated protein and insulin levels decreased, serum LDL and MDA decreased in the GK rats treated group, and histopathological changes in the kidney and pancreas of GK rats were improved. Conclusion: BGC has anti-diabetic effects.