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我们观察了中药复方制剂心脉灵注射液对实验性心力衰竭、心源性休克病理模型的作用,并进行了毒理学研究。该制剂对麻醉犬急性心力衰竭及心源性休克有明显保护作用,可增加心收缩力,与给药前比较左心室内压峰值(LVSP)升高40.55±18.88％,R-dp/dtmax缩短8.50±4.87％,并增加心输出量(CO)、收缩压(SBP)及输张压(DBP)(P<0.05)。对戊巴比妥钠诱发体外培养心肌细胞急性收缩功能衰竭,可延缓心肌细胞停搏,促进复跳。长期毒性实验表明,未发现毒性及异常,提示心脉灵注射液安全无毒。
We observed the effects of Chinese traditional medicine compound preparation (Xinmailing) on pathological models of experimental heart failure and cardiogenic shock, and conducted toxicological studies. The preparation has obvious protective effects on acute heart failure and cardiogenic shock in anesthetized dogs and can increase cardiac contractility. Compared with before administration, the peak value of left ventricular pressure (LVSP) is increased by 40.55±18.88%, and R-dp/dtmax is shortened. 8.50±4.87%, and increased cardiac output (CO), systolic blood pressure (SBP) and transfusion pressure (DBP) (P<0.05). Inducing acute contraction failure of cultured cardiomyocytes in vitro induced by pentobarbital can delay cardiac arrest and promote resuscitation. Long-term toxicity experiments showed that no toxicity and abnormalities were found, suggesting that Xinmailing injection is safe and non-toxic.