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目的:探讨辅助生殖技术(ART)助孕妊娠后晚期发生自然流产的相关因素。方法:回顾性分析2000年1月～2008年12月ART术后妊娠晚期自然流产的患者111例及同期ART后足月分娩的183例妇女,分析与晚期自然流产有关的因素。结果:ART后晚期流产的相关因素有宫颈操作次数(OR=1.356)、胎膜早破(OR=13.881)、减胎术(OR=5.363)、双胎妊娠(OR=1.136)。结论:行ART治疗的不孕患者如有多次宫腔操作史,后天性的宫颈管机械损伤不容忽视;当伴多胎妊娠时应严密监测宫颈长度,必要时行宫颈环扎术。
Objective: To explore the related factors of spontaneous abortion assisted pregnancy (ART). Methods: A retrospective analysis of 111 patients with spontaneous abortion in the third trimester of pregnancy after ART from January 2000 to December 2008 and 183 women of full term delivery during the same period were performed to analyze the factors related to late spontaneous abortion. Results: The related factors of late abortion after ART were the number of cervical operation (OR = 1.356), premature rupture of membranes (OR = 13.881), abortion reduction (OR = 5.363) and twin pregnancy (OR = 1.136). CONCLUSIONS: If infertility patients undergoing ART treatment have multiple uterine cavity operations history, the acquired cervical canal mechanical damage can not be ignored. Cervical cerclage should be closely monitored when multiple pregnancies occur. Cervical cerclage should be performed if necessary.