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目的:评价米非司酮与米索前列醇联用对瘢痕子宫产妇中期妊娠引产的影响。方法:选取2015年5月—2016年11月间收治的瘢痕子宫中期妊娠引产患者90例临床资料,将其随机分为传统方案组与新方案组(每组45例);传统方案组患者给予米非司酮和乳酸依沙吖啶注射液联用治疗,新方案组患者给予米非司酮与米索前列醇联用治疗,比较两组瘢痕子宫产妇用药后中期妊娠引产成功率,软产道裂伤、宫内残留和产后出血等并发症的发生率,以及发动宫缩时间、引产过程血量和总产程时间。结果:新方案组产妇用药后中期妊娠引产成功率高于传统方案组(P<0.05),软产道裂伤、宫内残留和产后出血等并发症的发生率低于传统方案组(P<0.05),产妇发动宫缩时间、引产过程血量和总产程时间少于传统方案组(P<0.05)。结论:采用米非司酮与米索前列醇联用对瘢痕子宫产妇中期妊娠引产的临床疗效优于米非司酮和乳酸依沙吖啶注射液联用,其并发症的发生率较低,引产过程中出血量较少。
Objective: To evaluate the effect of mifepristone combined with misoprostol on induction of labor in mid-term pregnancy of scar-shaped uterus. Methods: Ninety patients with induced abortion of scar uterus during pregnancy from May 2015 to November 2016 were selected and randomly divided into two groups: traditional group and new group (45 cases in each group); patients in traditional group Mifepristone and ethacridine lactate injection combination therapy, the new program group were given mifepristone and misoprostol combined treatment, compared the two groups of hyperthyroidism after maternal drug delivery rate of midterm pregnancy induction, soft birth canal Laceration, residual intrauterine and postpartum hemorrhage and other complications, as well as the onset of contractions time, the amount of labor induced labor and total labor time. Results: The success rate of induction of labor in the second trimester pregnancy was significantly higher in the new treatment group than in the conventional treatment group (P <0.05). The incidence of complications such as soft birth canal laceration, intrauterine residue and postpartum hemorrhage were lower than those in the traditional treatment group ), Maternal tardiness time, labor volume and duration of labor during labor were less than those in the conventional treatment group (P <0.05). Conclusions: The combination of mifepristone and misoprostol is superior to mifepristone and ethacridine lactate injection in the treatment of mid-term pregnancy induced abortion of scar uterus, the complication rate is lower, Less bleeding during induced labor.