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血压的体液调节主要靠血管紧张肽原酶—血管紧张肽酶系统和血管舒缓素—激肽系统。已有报道提出血管舒缓素—激肽系统对妊娠高血压疾病起重要的病因学作用。作者对严重先兆子痫非洲黑人妇女尿组织血管舒缓素排泄进行研究。 试验对象随机分配:1组:先兆子痫66例,舒张压≥14.7kPa(110mmHg),蛋白尿≥2~+;2组:66例血压正常孕妇、年龄、孕周和产次与1组相匹配;3组:66例血压正常、健康的非孕妇,年龄与前两组匹配。在孕28周和临近分娩日随机取15ml尿样本,测定组织血管舒缓素;另取5ml尿不加防腐剂测总蛋白。在常规实验室测定肾功能、全血计数和末梢血涂
Body fluid regulation of blood pressure depends mainly on the renin-angiotensin system and the kallikrein-kinin system. It has been reported that the kallikrein-kinin system plays an important etiological role in pregnancy-induced hypertension. The authors studied the excretion of the blood kallikrein in urinary tissue of black African women with severe preeclampsia. The subjects were randomly assigned to one of the following groups: group 1 66 preeclampsia, diastolic blood pressure 14.7 kPa (110 mmHg), and proteinuria 2 to + 2; group 2 66 pregnant women with normal blood pressure, age, gestational age, Matching; 3 groups: 66 cases of normal blood pressure, healthy non-pregnant women, age and the first two match. At 28 weeks of gestation and 15 days before birth, 15ml of urine samples were taken randomly to determine the tissue kallikrein. Another 5ml of urine was added to test the total protein without preservatives. Renal function, whole blood count, and peripheral blood smear were determined in a routine laboratory