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目的 研究急性胰腺炎 (AP)与内皮素 (ET)、一氧化氮 (NO)和氧自由基关系。方法 急性胰腺炎 71例 ,应用放射免疫分析法测定血浆ET、NO和超氧化物歧化酶 (SOD) ,并与健康体检者 15例作对照。结果 急性胰腺炎血浆ET、NO明显升高 ,而SOD明显降低 ,与健康对照组比较差异显著 (P <0 0 1) ;且重症胰腺炎的ET和NO增高、SOD降低尤为明显 ,与轻症胰腺炎相比较有统计学意义 (P <0 0 1)。结论 血浆的ET、NO和SOD异常消长在急性胰腺炎发生、发展过程中具有重要作用。
Objective To study the relationship between acute pancreatitis (AP) and endothelin (ET), nitric oxide (NO) and oxygen free radicals. Methods 71 cases of acute pancreatitis, plasma ET, NO and SOD were measured by radioimmunoassay, and compared with 15 healthy controls. Results The plasma levels of ET and NO in acute pancreatitis were significantly increased, while the levels of SOD were significantly lower in acute pancreatitis compared with those in healthy controls (P <0.01). The levels of ET and NO in severe pancreatitis increased significantly, especially in mild pancreatitis Pancreatitis was statistically significant (P <0.01). Conclusion The abnormal changes of plasma ET, NO and SOD may play an important role in the occurrence and development of acute pancreatitis.