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目的:探讨黄连与人参不同配伍剂量对水煎液中盐酸小檗碱、盐酸药根碱含量的影响。方法:人参黄连分别按1∶0,2∶1,1.5∶1,0.5∶1比例配伍,煎煮制备水煎液,采用HPLC测定不同配伍剂量水煎液中黄连生物碱的含量。结果:人参-黄连不同配伍样品中盐酸小檗碱质量分数分别为36.68,39.41,44.33 mg·g-1,盐酸药根碱分别为8.607,8.349,10.790 mg·g-1,二者含量随人参用量的减少而增加。结论:黄连-人参配伍后不利于盐酸小檗碱和盐酸药根碱的溶出,按0.5∶1配伍时黄连中2种生物碱含量均最高。
Objective: To investigate the effects of different compatibility of berberine and ginseng on the contents of berberine hydrochloride and jatrorrhizine hydrochloride in decoction. Method: The ginseng was mixed with 1: 2, 2: 1, 1.5: 1 and 0.5: 1 respectively according to the ratio of 1: 2, 1: 1 and 0.5: 1, decocted to prepare the decoction and the contents of Coptis alkaloids in different compatibility decoctions were determined by HPLC. Results: The contents of berberine hydrochloride in different compatibility samples of ginseng-berberine were 36.68, 39.41, 44.33 mg · g-1, and jatrorrhizine hydrochloride were 8.607, 8.349 and 10.790 mg · g-1, Increase the amount of reduction. Conclusion: Coptis - ginseng compatibility is not conducive to the dissolution of berberine hydrochloride and jatrorrhizine hydrochloride, 0.5:1 compatibility when the content of the two alkaloids in Coptis were the highest.