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目的研究不同胎龄早产儿发生胃肠功能障碍后胃液中表皮生长因子(EGF)水平变化,探讨其在胃肠功能障碍的病理生理过程中的作用,为寻找早期预测早产儿胃肠功能的客观指标提供理论依据。方法本院新生儿监护室2006年1月-2009年6月收治160例不同胎龄早产儿,随机分为胃肠功能障碍组80例(观察组)和非胃肠功能障碍组80例(对照组),采用ELISA方法检测其胃液中EGF水平变化,观察组收集样本时间均为症状表现12 h内,对照组为入院3 d内。结果观察组及对照组均按不同胎龄分为4组:28～30周组,30+1～32周组,32+1～34周组,34+1～36+6周组,每组20例,观察组胃液EGF质量浓度(ng.L-1)分别为68.2±11.4,172.0±34.4,284.8±30.6,444.4±82.4,对照组胃液EGF质量浓度(ng.L-1)分别为:343.0±45.2,494.4±29.4,703.3±118.1,947.8±158.1,EGF随胎龄不同,分泌水平随之变化,胎龄越大,其表达水平越高。胃肠道EGF的分泌水平与胎龄呈正相关。结论早产儿胃肠衰竭时EGF分泌水平明显降低,反映了胃肠道功能的损害程度。
Objective To study the changes of epidermal growth factor (EGF) in gastric juice after gastrointestinal dysfunction in different gestational age preterm infants, and to explore the role of epidermal growth factor (EGF) in the pathophysiology of gastrointestinal dysfunction. In order to find out the objective of early predicting gastrointestinal function in preterm infants Indicators provide a theoretical basis. Methods A total of 160 preterm infants with different gestational age were enrolled in our neonatal care unit from January 2006 to June 2009 and were randomly divided into 80 cases (observation group) and 80 cases (non-gastrointestinal dysfunction group) of gastrointestinal dysfunction group Group). The changes of EGF level in gastric juice were detected by ELISA. The time of collection in the observation group was within 12 hours and the control group was within 3 days after admission. Results The observation group and the control group were divided into 4 groups according to different gestational age: 28-30 weeks group, 30 + 1 ~ 32 weeks group, 32 + 1 ~ 34 weeks group, 34 + 1 ~ 36 + 6 weeks group, each group The gastric mucosal EGF concentration (ng.L-1) in the observation group were 68.2 ± 11.4,172.0 ± 34.4,284.8 ± 30.6 and 444.4 ± 82.4, respectively. The gastric mucosal EGF concentration in the control group (ng.L-1) 343.0 ± 45.2, 494.4 ± 29.4, 703.3 ± 118.1, 947.8 ± 158.1. The levels of EGF changed with the different gestational ages. The higher the gestational age, the higher the expression level of EGF. Gastrointestinal EGF secretion was positively correlated with gestational age. Conclusions EGF secretion in preterm infants with gastrointestinal failure is significantly reduced, reflecting the extent of damage to gastrointestinal function.