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目的:观察当归补血汤加味对大肠癌术后化疗减毒增效的作用。方法:将60例大肠癌患者随机分为对照组(30例)和观察组(30例)两组,并检测两组患者治疗前后毒副反应发生和生活质量变化。结果:经治疗后,对照组有效率为37.5%(CR0例、PR12例、NC12例、PD6例);观察组有效率为48.4%(CR0例、PR 12例、NC 12例、PD 6例)。与对照组相比,观察组总有效率虽无显著差异(P>0.05),但较对照组明显提高。此外,观察组治疗后患者的生活质量(KS评分升高)明显改善、毒副反应的发生减轻(骨髓抑制率、肝肾功能异常率及胃肠道反应均明显降低),且效果明显优于对照组(P<0.05)。结论:当归补血汤加味联合常规大肠癌化疗可提高机体免疫功能、改善患者生活质量、表明该法具有减毒增效作用,值得临床推广运用。
Objective: To observe the role of Danggu Buxue Decoction in reducing the toxicity and increasing the efficiency of postoperative chemotherapy of colorectal cancer. Methods: Sixty patients with colorectal cancer were randomly divided into control group (30 cases) and observation group (30 cases). The incidence of toxic and side effects and quality of life before and after treatment were detected in both groups. Results: After treatment, the effective rate of the control group was 37.5% (CR0 cases, PR12 cases, NC12 cases and PD6 cases); the effective rate of the observation group was 48.4% (CR0 cases, PR 12 cases, NC 12 cases and PD 6 cases) . Compared with the control group, the total effective rate of observation group, although no significant difference (P> 0.05), but significantly higher than the control group. In addition, the quality of life (KS score) was significantly improved and the occurrence of toxic and side effects (bone marrow suppression, abnormal liver and kidney function and gastrointestinal reactions were significantly lower) in the observation group after treatment, and the effect was significantly better Control group (P <0.05). Conclusion: Dangguibuxuetang combined with conventional colorectal cancer chemotherapy can improve the body’s immune function and improve the quality of life of patients, indicating that the method has the effect of attenuation and synergy, worthy of clinical promotion and use.