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目的研究长效5-单硝酸异山梨醇酯(抗心绞痛药)对健康人外周动脉血压、中心动脉血压以及血管弹性的动态影响。方法采用自身对照实验设计,18例健康成年男性,早7:00空腹单次给药60 mg;比较服药前1天和服药当天从6:30到23:00期间的血压、脉搏波和心率的变化情况。结果服用5-单硝酸异山梨醇酯后,中心动脉脉压和反射波增加指数均下降,与前1天的基线相比有显著性差异(P<0.05);收缩压和舒张压和心率没有明显变化。结论5-单硝酸异山梨醇酯能明显改善血管顺应性和降低中心动脉脉压。
Objective To investigate the dynamic effects of long-acting isosorbide-5-mononitrate (anti-anginal medicine) on peripheral arterial pressure, central arterial pressure and blood vessel elasticity in healthy volunteers. Methods A total of 18 healthy adult male subjects were given a single dose of 60 mg fasting fasting at 7:00 a.m., using the self-controlled experimental design. The blood pressure, pulse wave and heart rate were compared between the day before and 1 day of medication and from 6:30 to 23:00 on the day of medication Changes. Results After 5-isosorbide mononitrate administration, the increase of central arterial pressure and reflected wave index decreased, compared with the baseline of the previous day (P <0.05); systolic and diastolic blood pressure and heart rate did not obvious change. Conclusion Isosorbide 5-mononitrate can significantly improve vascular compliance and reduce central arterial pressure.