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重症有机碘农药中毒治疗中易出现病情的反复,并可因此迅速导致死亡,这在临床上称之为“反跳”现象。目前,对于反跳的原因尚无一致认识。在临床上造成病情反复的原因分析有如下几种可能:(1)抢救早期抗毒药物用量不足;或经过抢救病情缓解后过早停药或减量太快;(2)由于中毒时间较久或洗胃不够彻底,造成胃肠道内继续吸收毒物,毒物持续地抑制胆碱酯酶,使体内乙酰胆碱蓄积引起反跳;(3)由于有机磷对中枢神经系统的直接毒性作用,以及缺氧等引起脑水肿,所以对昏迷患者应用脱水剂防止反跳是有益的;(4)缺乏细致的病情观察,尤其对病情反复早期表
Severe organic iodine pesticide poisoning treatment prone to repeated illness, and can thus quickly lead to death, which clinically called “rebound” phenomenon. At present, there is no consensus on the reasons for rebound. In clinical analysis of the causes of repeated illness has the following possibilities: (1) the rescue of early anti-drug drugs in the amount of insufficient; or after rescuing the disease premature withdrawal or reduction too fast; (2) due to poisoning time longer Or lack of thorough gastric lavage, resulting in continued absorption of toxic substances in the gastrointestinal tract, toxic continued inhibition of cholinesterase, the body caused by acetylcholine accumulation rebound; (3) due to the direct toxicity of organophosphate on the central nervous system, and hypoxia Causing brain edema, so the use of dehydration agent in patients with coma to prevent rebound is beneficial; (4) the lack of detailed observation of the disease, especially for the disease repeatedly early table