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目的探讨埃索美拉唑与奥美拉唑治疗老年消化性溃疡的疗效比较。方法选取67例幽门螺杆菌(HP)阳性,年龄在60～78岁的消化性溃疡患者,其中十二指肠球部溃疡2S例,胃溃疡39例,随机分成两组。第1组:埃索美拉唑20mg+阿莫西林1000mg+呋喃唑酮100mg,bid;第2组:奥美拉唑20mg+阿莫西林1000mg+呋喃唑酮100mg,bid。两组疗程均为7 d。7d后,第1组继续给予埃索芙拉唑20mg,qd,疗程3周;第2组继续给予奥美拉唑20mg,qd,疗程3周。观察各组患者症状缓解情况、HP根除率、不良反应及溃疡愈合率。结果第1组HP根除率为93.94%,第2组的HP根除率为85.29%。第1组患者上腹痛、反酸、烧心症状的缓解优于第2组。溃疡愈合率分别为90.91%,88.24%。结论两组在溃疡愈合及HP根除率方面具有相同疗效,第1组对胃肠道症状的缓解明显优于第2组,顺从性和耐受性好。
Objective To investigate the efficacy of esomeprazole and omeprazole in the treatment of senile peptic ulcer. Methods Seventy-six patients with peptic ulcer of Helicobacter pylori (HP) positive and 60 to 78 years old were selected. Among them, there were 2 cases of duodenal ulcer and 39 cases of gastric ulcer. They were randomly divided into two groups. Group 1: esomeprazole 20mg + amoxicillin 1000mg + furazolidone 100mg, bid; Group 2: omeprazole 20mg + amoxicillin 1000mg + furazolidone 100mg, bid. The two courses of treatment were 7 d. After 7d, the first group continued to give esophafrazole 20mg, qd, treatment for 3 weeks; the second group continued to give omeprazole 20mg, qd, treatment for 3 weeks. The symptom relief, HP eradication rate, adverse reactions and healing rate of ulcer in each group were observed. Results The first group HP eradication rate was 93.94%, the second group HP eradication rate was 85.29%. Group 1 patients with abdominal pain, acid reflux, heart symptoms relieve better than the second group. The healing rates of ulcer were 90.91% and 88.24% respectively. Conclusions The two groups have the same curative effect in the healing of ulcer and the eradication rate of HP. The relief of gastrointestinal symptoms in group 1 is obviously better than that in group 2, and the compliance and tolerability are good.