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Epstein-Barr病毒(EBV)与多种淋巴瘤相关,尤其是结外NK/T细胞淋巴瘤和血管免疫母细胞淋巴瘤,几乎所有患者肿瘤细胞均可检测到EBV-DNA。EBV诱发淋巴瘤发生的机制仍未十分明确,现有研究显示EBV感染宿主细胞后进入潜伏模式,即病毒停止表达其大部分基因以逃避免疫监视,仅表达部分功能基因参与宿主基因组的调控,影响细胞的增殖和转化。近年来还有研究显示EBV能产生miRNAs调控病毒及宿主基因,以实
Epstein-Barr virus (EBV) is associated with a variety of lymphomas, especially extranodal NK / T cell lymphoma and angioimmunoblastic lymphoma, with EBV-DNA detectable in almost all patient tumor cells. The mechanism of EBV-induced lymphoma remains unclear. Previous studies have shown that EBV enters the latent mode after infection of host cells, that is, the virus stops expressing most of its genes to evade immune surveillance, and only some of the functional genes are expressed in the host genome, affecting Cell proliferation and transformation. In recent years, there are studies have shown that EBV can produce miRNAs to regulate viruses and host genes, in order to real