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目的针对急性心肌梗死早期患者(发病3h内),分别进行静脉滴注国产尿激酶溶栓治疗和急诊行PCI术,对比分析两种治疗方法的临床疗效,并观察其不良反应。方法首次发生ST段抬高的AMI患者共229例,其中131例患者接受静脉溶栓治疗(溶栓组),98例接受急诊介入治疗(急诊组)。两组均于发病3h内进行治疗;对比分析患者TIMI血流情况、治疗后主要心血管事件发生率等因素。结果梗塞相关血管再通率无显著性差异(P>0.05);两组院内死亡率、院内无事件生存率、2周后超声心动图结果比较,差异有统计学意义(P>0.05)。结论急性心肌梗死患者早期(发病3h内)静脉滴注国产尿激酶进行溶栓治疗与急诊行PCI术作用相近。
Objective To investigate the curative effect of two kinds of treatment methods and to observe the adverse reactions of intravenous infusion of urokinase thrombolytic therapy and emergency PCI in the early stage of acute myocardial infarction (within 3 hours of onset). METHODS: A total of 229 AMI patients with ST-segment elevation AMI were enrolled in this study. Of these, 131 received intravenous thrombolytic therapy (thrombolytic therapy) and 98 received emergency intervention (emergency therapy). Both groups were treated within 3h after onset; the TIMI blood flow and the incidence of major cardiovascular events after treatment were compared and analyzed. Results There was no significant difference in infarct-related vascular recanalization rate (P> 0.05). There was significant difference in hospital mortality, hospital-free event-free survival and echocardiographic results after 2 weeks (P> 0.05). Conclusion Intravenous infusion of domestic urokinase for thrombolytic therapy in patients with acute myocardial infarction in early (within 3h of onset) is similar to emergency PCI.