论文部分内容阅读
目的探讨精蛋白锌重组赖脯胰岛素混合注射液(25R)联合吡格列酮治疗2型糖尿病(T2DM)的临床疗效。方法根据治疗方法将我院102例T2DM患者分为两组各51例,对照组给予精蛋白锌重组赖脯胰岛素混合注射液(25R)治疗,治疗组在对照组基础上加用吡格列酮治疗,比较两组患者的空腹血糖含量和餐后2h的平均血糖以及治疗前后HbA1c和胰岛素用量。结果治疗后,治疗组的空腹血糖含量和餐后2h平均血糖均显著低于对照组,HbA1c和胰岛素治疗用量均显著低于对照组(P<0.05)。结论精蛋白锌重组赖脯胰岛素混合注射液(25R)联合吡格列酮治疗T2DM能显著降低空腹血糖和餐后血糖,临床效果显著。
Objective To investigate the clinical efficacy of protamine zinc combined with insulin lispro injection (25R) combined with pioglitazone in the treatment of type 2 diabetes mellitus (T2DM). Methods According to the method of treatment, 102 cases of T2DM in our hospital were divided into two groups (n = 51). The control group was treated with protamine zinc combined with insulin lispro injection (25R). The treatment group was treated with pioglitazone on the basis of the control group. Fasting plasma glucose and mean postprandial blood glucose 2h after treatment and HbA1c and insulin levels before and after treatment in both groups. Results After treatment, fasting blood glucose and mean blood glucose at 2h after treatment were significantly lower in the treatment group than those in the control group. HbA1c and insulin dosage were significantly lower than those in the control group (P <0.05). Conclusion The treatment of T2DM with protamine zinc combined with insulin lispro injection (25R) and pioglitazone can significantly reduce the fasting blood glucose and postprandial blood glucose, and the clinical effect is remarkable.