【摘 要】
：
A series of isopentenyl-derived unsaturated alkyl ethers 19-31 of racemic deoxyisopodophyllotoxin were designed and synthesized. For comparison, compound 32 wit
【机 构】
：
Department of Traditional Chinese Medicine and Natural Drug Research,ZJU-ENS Joint Laboratory of Med
论文部分内容阅读
A series of isopentenyl-derived unsaturated alkyl ethers 19-31 of racemic deoxyisopodophyllotoxin were designed and synthesized. For comparison, compound 32 with a benzyl group at the same position was also prepared. The cytotoxicities of the synthetic compounds have been screened for six human tumor cell lines such as KB, BEL-7404, A549, Hela, PC-3 and CNE.The results showed that two of them exhibited significant cytotoxicities with their IC50 values on selected cell lines at μmol/L scale.
其他文献
A new C21 steroidal glycoside, named cynanversicoside F (1), was isolated from the root of Cynanchum versicolor Bunge. Its structure was established as glaucoge
The Schiff base, 2- { (2'-benzyl)iminoethyl} -5-methoxyphenol (C6H4CH2N=C(CH3)C6H3-(OMe-5)OH) 1, was synthesized and characterized by elemental analysis, IR and
Despite its role in disease there is still no definitive method to assess oesophago-gastric junction competence (OGJ). Traditionally the OGJ has been assessed u
Immobilizing chiral 1,1'-bi-2-naphthol (BINOL) in one step onto polymer backbone via stable carbon-carbon bond through Suzuki reaction was achieved. The applica
Complex formation between aluminium and quercetin(Q) in methanol was investigated by means of 27 Al solid-state, 13C and 1H NMR and MS(ESI), UV and IR spectra.
The photocatalytic hydrogen evolution and electrochemical behaviors of Kiggen-type XW12O40n- (X=P, Ge and Si) are investigated. It is found that the two-electro
The synthesis of four analogs of philanthotoxin is described. The preliminary bioassay showed that these compounds all had good insecticidal activities, and the
Using the classical Lie method of infinitesimals, we first obtain the symmetry of the (2+1)-dimensional Burgers-Korteweg-de-Vries (3D-BKdV) equation. Then we re
This paper introduces an effective method for seeking localconservation laws of general partial differential equations (PDEs). The well-known variational princi