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目的:观察健脾消癥法治疗晚期复治大肠癌的疗效。方法:将入选的64例患者分为单纯中医药组(A)18例、中医药配合化疗组(B)24例和单纯化疗组(C)22例,21天为1个疗程,观察3个疗程,评估患者治疗前后体力状况、体重及临床症状,检测NK细胞活性及T淋巴细胞亚群,并对患者生存期进行随访。结果:A组及B组患者NK、CD4/CD8较治疗前明显增高(P<0.05);3组对比,A组及B组NK细胞、CD4/CD8治疗后与C组相比有显著性差异(P<0.05);A组患者卡氏评分及体重均较治疗前增加,腹痛、便血、腹泻症状可明显改善,与C组比较有明显差异;并且应用中药的患者骨髓抑制情况及消化道反应明显轻于单纯化疗组;随访1年,仍生存者A组及B组优于C组(P<0.05)。结论:健脾消法治疗晚期复治大肠癌可明显改善患者免疫功能状态,提高患者生存质量,延长患者生存期。
Objective: To observe the curative effect of Jianpi Xiaozheng method in the treatment of advanced colorectal cancer. Methods: The selected 64 patients were divided into simple Chinese medicine group (A) 18 cases, Chinese medicine combined chemotherapy group (B) 24 cases and chemotherapy group (C) 22 cases, 21 days for a course of treatment, observed 3 Course of treatment, physical status, body weight and clinical symptoms of patients before and after treatment to assess the activity of NK cells and T lymphocyte subsets, and the survival of patients were followed up. Results: NK and CD4 / CD8 in group A and group B were significantly higher than those before treatment (P <0.05). Compared with group C, the numbers of NK cells and CD4 / CD8 in group A and group B were significantly different from those in group C (P <0.05). The Karnofsky scores and body weight of patients in group A were significantly higher than those before treatment, and the symptoms of abdominal pain, blood in the stool and diarrhea were significantly improved, which were significantly different from those in group C. The bone marrow suppression and digestive tract reactions Was significantly lighter than simple chemotherapy group; 1 year follow-up, survivors A group and B group was better than C group (P <0.05). Conclusion: Jianpixiao Therapy for the treatment of advanced colorectal cancer can significantly improve the patient’s immune function, improve the quality of life of patients and prolong the survival of patients.