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目的:观察氧化槐定碱(oxysophoridine,OSR)对麻醉大鼠中脑网状结构脑生物电(EEG)变化及功率谱的影响。方法:利用脑立体定位技术,将电极置入大鼠中脑网状结构,采用单极引导法及计算机辅助FFT技术以脑电图、功率谱、频率分配为指标记录并分析OSR对大鼠中脑网状结构脑生物电变化的影响。结果:每只侧脑室注射(icv)OSR2.5,5,10mg,大鼠中脑网状结构出现以低幅慢波为主并伴有梭形睡眠波;脑电总功率下降(P<0.05),θ,α波占总频率比例升高(P<0.05)。结论:OSR具有中枢抑制作用,其作用与降低大鼠中脑网状结构电活动有关;中脑网状结构可能是OSR中枢抑制作用传导环路上的结构之一。
OBJECTIVE: To observe the effects of oxysophoridine (OSR) on the brain bioelectricity (EEG) changes and power spectrum in the midbrain reticular formation of anesthetized rats. METHODS: Using a three-dimensional brain localization technique, the electrodes were placed into the midbrain reticular formation of the rat. The unipolar guiding method and computer-assisted FFT were used to record and analyze the OSR in the rat using EEG, power spectrum, and frequency assignment. Brain reticular structure brain bioelectrical changes. RESULTS: After each lateral ventricle was injected with (icv) OSR2.5, 5, and 10 mg, the rat brain reticular formation was dominated by low-amplitude slow waves with spindle-shaped sleep waves; total brain power decreased (P<0.05). ), θ, α wave proportion of the total frequency increased (P <0.05). CONCLUSION: OSR has a central inhibitory effect and its effect is related to the decrease of electrical activity in the rat midbrain reticular formation. The midbrain reticular formation may be one of the structures on the conduction loop of the OSR central inhibition.