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从新疆产胀果甘草(Glycyrrhiza inflata But)中分得甘草查耳酮(1) ,C_(21) H_(22) O_4,熔点136～138℃,经光谱分析及碱裂解产物的分析与合成以及1的全合成证明为一新型查耳酮--2-甲氧基-4,4′-二羟基-5-α,α-二甲烯丙基查耳酮.碱裂解产物为对羟基苯乙酮与3-α,α-二甲烯丙基-4-羟基-6-甲氧基苯甲醛(2) ,C_(13) H_(16) O_3,熔点187～188℃.后者经甲基化、氢化与高锰酸钾氧化得3-α,α-二甲丙基-4,6-二甲氧基苯甲酸(3) ,C_(14) H_(20) O_4,熔点124～125℃.1,2,3的结构均经合成证明.2-甲氧基-4-羟基-苯甲醛与溴代异戊烯作用得异戊烯醚(4) ,再经Claisen 重排得2. 2与对羟基苯乙酮缩合成1. 探索了提高 Claisen 重排产率的较佳条件.
The licorice chalcone (1), C 21 H 22 O 4 are obtained from Xinjiang Glycyrrhiza inflata But, the melting point is 136 ~ 138 ℃, and the results of spectral analysis and alkali pyrolysis analysis and synthesis 1 of the total synthesis proved to be a new type of chalcone - 2-methoxy-4,4’-dihydroxy-5-α, α-dimethyl-allyl chalcone alkali cracking product is p-hydroxy phenethyl Ketone and 3-α, α-diallyl-4-hydroxy-6-methoxybenzaldehyde (2), C 13 H 16 O 3, the melting point of 187 ~ 188 ° C. The latter methyl (3), C_ (14) H_ (20) O_4, the melting point of which is 124 ~ 125 ℃, and the oxidation of potassium permanganate to 3-α, α-dimethylpropyl-4,6-dimethoxybenzoic acid .1,2,3 structure have been synthesized to prove .2-methoxy-4-hydroxy-benzaldehyde and bromine isopentenyl had pentenyl ether (4), and then rearranged by Claisen 2.2 Condensation with p-hydroxyacetophenone to 1. Better conditions for increasing Claisen rearrangement yield were explored.