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目的:探讨椎体成形术在绵羊骨质疏松脱矿化椎体模型中的生物力学性能变化及可行性.方法:选取绵羊椎体标本30个,随机分为3组,其中A组为未脱钙组,空白对照组;B组为4 h脱钙后椎体成形组;C组为4 h脱钙后假手术组.B、C两组运用微量注射泵向椎体内灌注盐酸及椎体整体浸泡的脱钙方法,快速建立绵羊腰椎骨质疏松脱矿化椎体模型,10个椎体/组.通过骨密度、影像学及生物力学检测,评估椎体成形术在模型中应用的可行性及力学性能变化.结果:BMD检测提示,B、C组模型经脱钙处理后,BMD下降范围在25%~35%,两组比较,差异无统计学意义(P>0.05);与A组比较,差异有统计学意义(P<0.05).X线及CT检查提示椎体成形术在体外模型上具有可操作性,操作程序、骨水泥填充情况与体内及临床试验基本一致.力学实验提示椎体成形术可显著提高椎体的最大抗压强度,各组间比较,差异有统计学意义(P<0.05).结论:绵羊椎体骨质疏松脱矿化模型可以用于椎体成形术的实验研究,并为进一步研究提供理论依据.
Objective: To investigate the biomechanical changes and feasibility of vertebroplasty in sheep osteoporosis demineralized vertebral model.Methods: 30 sheep vertebral specimens were selected and randomly divided into 3 groups, in which group A was not detached Calcium group and blank control group.The B group was 4 h decalcified vertebroplasty group and the C group was 4 h decalcified sham operation group.B group and C group were injected with hydrochloric acid and vertebral body Whole Decoction Decalcification Method To establish a sheep lumbar osteoporosis demineralized vertebral model and 10 vertebrae / group rapidly.It is feasible to evaluate the application of vertebroplasty in the model through the bone density, imaging and biomechanical testing BMD decreased from 25% to 35% in group B and group C after decalcification treatment, the difference was not statistically significant (P> 0.05) (P <0.05) .X-ray and CT examination showed that vertebroplasty was feasible in vitro, and the operation procedure and the filling of bone cement were basically the same as those in vivo and in clinical trials. Tip vertebroplasty can significantly increase the vertebral maximum compressive strength, compared between the groups, the difference was statistically significant (P <0.05) Conclusion: osteoporotic vertebral demineralization sheep model may be used to study experimental surgery vertebroplasty, and to provide a theoretical basis for further research.