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一般认为门脉高压只存在于慢性肝病时,而在急性肝病时无门脉高压。本研究目的是证明在暴发型病毒性肝炎时,门脉高压经常存在。作者研究了10例连续收住院的暴发型病毒性肝炎。诊断系根据下列资料:①无肝炎既往史;②无其他致病原因,特别是无服对肝脏有毒性药物的病史:③有黄疸;④有肝性脑病;⑤转氨酶增高;⑥凝血因子明显缺乏。其中3例病人 HBsAg 阳性,肝脏组织学检查(经肝静脉进行活检)发现肝支撑结构正常,而肝细胞则大量坏死。有7例病人出现腹水,4例病人经治疗后存活。
Generally believed that portal hypertension exists only in chronic liver disease, and in the absence of portal hypertension in acute liver disease. The purpose of this study was to demonstrate that portal hypertension is often present in fulminant viral hepatitis. The authors studied 10 consecutive hospitalized fulminant viral hepatitis. Department of diagnosis based on the following information: ① no past history of hepatitis; ② no other causes of disease, especially no evidence of liver toxic drugs: jaundice; ④ have hepatic encephalopathy; ⑤ aminotransferase increased; ⑥ significant lack of clotting factor . Three of the patients had positive HBsAg and liver histology (via biopsy of the hepatic vein) found that the liver support structure was normal, while the liver cells were largely necrotic. Ascites occurred in seven patients and survived after treatment in four patients.