论文部分内容阅读
脂肪乳剂对胃癌术后患者免疫功能的影响目前还存在着争论.本文旨在通过检测胃癌根治术后患者的 IL-12及 T 细胞亚群,了解输注脂肪乳剂对机体免疫功能的影响.1 材料和方法1.1 材料选择术前经病理证实的胃癌住院患者34例,随机分成2组:实验组(TPN)组20例,对照组14例.入选条件:①有典型的临床症状;②肝功能正常,无代谢性疾病,术前未应用免疫治疗或放、化疗;③术前无明显重要脏器转移.两组患者的临床资料、肿瘤部位、病理类型、分期、手术方式等均无显著差异,手术探查证实均无邻近及重要脏器转移.另取16份正常人血清做正常人群对照.1.2 方法实验组术后 d1起,每天静脉输注200 g/L 脂肪乳剂250mL,70 g/L 乐凡命1000mL,100 g/L 葡萄糖液2000mL,连用8 d～9 d;对照组术后给予常规补液,无脂肪乳剂及氮供给.
The effect of fat emulsion on immune function in patients with gastric cancer remains controversial.This paper aims to understand the effects of lipid emulsion on immune function by detecting IL-12 and T cell subsets in patients with gastric cancer after radical operation.1. Materials and Methods 1.1 Materials Selection 34 cases of pathologically confirmed inpatients with gastric cancer were randomly divided into two groups: 20 cases in the experimental group (TPN) and 14 cases in the control group.Conditions: ① typical clinical symptoms; ② liver function Normal, no metabolic diseases, no preoperative immunotherapy or radiotherapy and chemotherapy; ③ no significant organ metastasis before surgery.The two groups of patients with clinical data, tumor location, pathological type, stage, surgical methods were no significant difference , Surgical exploration confirmed no adjacent and important organs metastasis.Other 16 normal human serum as a normal population control.1.2 Methods Experimental group after operation d1, daily intravenous infusion of 200 g / L fat emulsion 250mL, 70 g / L Lifanmai 1000mL, 100g / L glucose solution 2000mL, once every 8d ~ 9d; control group was given routine rehydration, fat-free emulsion and nitrogen supply.