论文部分内容阅读
目的:观察阿奇霉素与红霉素在治疗小儿支原体肺炎方面的临床疗效。方法:将130例患儿随机分为两组,即阿奇霉素组和红霉素组。阿奇霉素组给予马来酸阿奇霉素8~10 mg.kg-1.d-1加入5%葡萄糖注射液静脉滴注,1次/天,疗程为4~5天,有肺外表现者5~7天。红霉素组给予乳糖酸红霉素20~30 mg.kg-1.d-1加入5%葡萄糖注射液静脉滴注,2次/天,疗程为7~14天。比较两组总有效率、临床症状、不良反应的差异。结果:总有效率阿奇霉素组91.4%,红霉素组78.3%,有统计学差异(P<0.05);两组临床症状比较阿奇霉素组优于红霉素组,不良反应发生方面阿奇霉素组明显低于红霉素组(P<0.05)。结论:阿奇霉素在治疗小儿支原体肺炎方面比红霉素更加安全有效,值得进一步推广应用。
Objective: To observe the clinical efficacy of azithromycin and erythromycin in the treatment of children with mycoplasma pneumonia. Methods: 130 children were randomly divided into two groups: azithromycin group and erythromycin group. The azithromycin group was given azithromycin maleate 8-10 mg.kg-1.d-1 by adding 5% glucose injection intravenously once a day for 4 to 5 days, with extrapulmonary performance of 5 to 7 days . Erythromycin group was given erythromycin lactobionate 20 ~ 30 mg.kg-1.d-1 by adding 5% glucose injection intravenously, 2 times / day, the course of treatment is 7 to 14 days. The total effective rate, clinical symptoms and adverse reactions were compared between the two groups. Results: The total effective rate was 91.4% in azithromycin group and 78.3% in erythromycin group (P <0.05). The clinical symptoms of the two groups were better than that of the erythromycin group and the azithromycin group was significantly lower than the azithromycin group Erythromycin group (P <0.05). Conclusion: Azithromycin is safer and more effective than erythromycin in the treatment of children with mycoplasmal pneumonia, which is worth further promotion and application.