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目的探讨缺氧诱导因子HIF-1α在妊娠高血压综合征(PIH)中的作用。方法采用免疫组化法检测40例PIH患者和40例正常妊娠孕妇胎盘组织中HIF-1α的表达。结果PIH患者胎盘组织中HIF-1α高于正常妊娠对照组,中度、重度PIH组HIF-1α与正常对照组相比差异均有显著性(P<0.01),中度组高于轻度组(P<0.01),重度组高于中度组(P<0.01)。结论HIF-1α参与了PIH缺氧的病理生理改变,而且HIF-1α在PIH患者胎盘组织中的表达与PIH的严重程度有关。
Objective To investigate the role of hypoxia inducible factor (HIF-1α) in pregnancy induced hypertension (PIH). Methods Immunohistochemistry was used to detect the expression of HIF-1α in placenta of 40 PIH patients and 40 normal pregnant women. Results The HIF-1α in placenta of patients with PIH was higher than that of normal pregnant controls, while the levels of HIF-1α in moderate and severe PIH were significantly higher than those in normal controls (P <0.01) (P <0.01), severe group was higher than the moderate group (P <0.01). Conclusion HIF-1α participates in the pathophysiological changes of PIH hypoxia, and the expression of HIF-1α in placenta of PIH patients is related to the severity of PIH.