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本文是美国防病中心和17个地区有关部门对结核病耐药和敏感病例的传染性危险问题共同研究的结果。有统一的做法和标准。共选择398例耐INH或/及耐SM的病例,并随机抽取相应的敏感病例作对照,其中有些病例的结菌还对另7种抗痨药中的一、两种也耐药。主要从病家15岁以下有接触儿童中,寻找耐药病例与敏感病例接触儿童的感染和发病,究竟有何不同。结果1,405铡接触者中,已受检接触者共1,352人占96%,其中0～24岁299人占22.1%。1,352例已受检的接触者中491人已被感染占36.3%,10人已发病。耐药病例接触者的感染率明显高于敏感病例接触者的感染率,呈39.8%:33.6%(P=0.02);而耐药病例接触者发病4人,敏感病例接触者发病6人,无明显差别。1.未经化疗的耐药病例与未经化疗的敏感病例
This article is the result of a joint study by the Centers for Disease Control of the United States and 17 regional authorities on the communicable danger of drug-resistant and sensitive cases of tuberculosis. Have a unified approach and standards. A total of 398 cases of INH-resistant and / or SM-resistant cases were selected and the corresponding sensitive cases were randomly selected as controls. In some cases, the mycobacteria were also resistant to one or two of the other seven anti-tuberculosis drugs. Mainly from the sick under the age of 15 with contact with children, looking for drug-resistant cases and sensitive cases of exposure to children with the infection and the incidence, what is the difference. Results Among 1,405 contacts, a total of 1,352 contacts were detected, accounting for 96%, of which 299 were 0-24 years old accounting for 22.1%. Of the 1,352 contacts tested, 491 had been infected with 36.3% of the contacts and 10 had been affected. The infection rate of drug-resistant cases was significantly higher than that of susceptible cases (39.8%): 33.6% (P = 0.02); while the incidence of drug-resistant cases was 4, that of sensitive cases was 6, and none Obvious difference. 1. Chemotherapy-naive cases and non-chemotherapy-sensitive cases