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目的介绍冬凌草甲素靶向制剂的研究现状。方法综述近年来国内外相关研究,介绍靶向制剂靶向原理和特性、药动药效学研究进展,并对其可行性和前景进行分析。结果冬凌草甲素靶向制剂不仅可以提高冬凌草甲素的溶解度,而且提高了靶部位药物浓度,增强抗肿瘤效果、降低不良反应。结论开发更高靶向效率、安全、经济、多类型的给药系统是未来冬凌草甲素靶向制剂的研究焦点。
Objective To introduce the research status of oridonin targeting agents. Methods This review summarizes the recent researches at home and abroad, introduces the targeting principles and properties of targeted agents, and advances in pharmacokinetics and pharmacodynamics, and analyzes their feasibility and prospect. The results of oridonin targeting agents can not only improve the solubility of oridonin, but also improve the drug concentration at the target site, enhance the anti-tumor effect, reduce adverse reactions. Conclusion The development of more targeted, safe, economical and multi-drug delivery systems is the focus of the research on the targeted preparations of oridonin.